I have this problem too. I have an x86_64 system and skype is an i386 package. I noticed that alsa-plugins-pulseaudio-1.0.14-5.fc8 is not available as mulitlib. I got the error ALSA lib control.c:874:(snd_ctl_open_conf) Cannot open shared library /usr/lib/alsa-lib/libasound_module_ctl_pulse.so ALSA lib control.c:874:(snd_ctl_open_conf) Cannot open shared library /usr/lib/alsa-lib/libasound_module_ctl_pulse.so ALSA lib control.c:874:(snd_ctl_open_conf) Cannot open shared library /usr/lib/alsa-lib/libasound_module_ctl_pulse.so and after manually install of alsa-plugins-pulseaudio from i386 repository, it doesn't come anymore, but sound doesn't work. On 17/10 I made a call from rawhide with skype 1.4.0 so I think the problem could be with alsa patches and/or pulseaudio after that date. NOTES: 1) when connecting headphones and playing sample audio, I have only on right side, while few weeks ago it was ok 2) how to disable pulseaudio and use alsa directly? alsamixer gives only pulseaudio interface.... 3) I also tried with no sound skype 2.0 beta 4) problem is both with 42 and 49 kernel Gianluca