Accessible Distros for a beginner?

[Linux for blind general discussion]

And even if NVDA can run under Wine, I would expect it to only work
with other Windows applications running under Wine.

And honestly, I remember Wine being fairly frustrating to work with
even as a sighted user, and while there's been nearly a decade for it
to improve since I last used it, Microsoft's fondness for overhauling
UI every other version and making changes seemingly for the sake of
change means the Wine devs have been dealing with a moving target...
wouldn't be surprised if Wine offers better support for older Windows
software than Windows itself does these days though.